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Isle of Palms, SC 5+ Bedroom Vacation Rentals

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128 rentals found
Beautiful Ocean Views w/ Pool and Elevat...

2301 Palm BoulevardProperty Highlights- Substantial Private Pool - Can Be Heated - Across the Street from Beach Access Path- Rooftop Deck with Ocean Vistas- Elevator- $250 Beach Gear Credit with 3-14 nighttime stays!Please note that every...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 14
Near Beach 5BR/5.5BA Isle of Palms w/ Pr...

Bright and roomy near the beach on Isle of Palms, this welcoming 5-bedroom, 5.5-bath home is designed for simple coastal living and memorable group getaways. With room for up to 12 guests, it blends comfort, convenience, and a casual vacation vibe...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Private Pool + Beach Access + Resort Ame...

Fishers Alley 5 by Wild Dunes6 Bedrooms | 6 Bathrooms | Sleeps 12 | Reserve________________________________________Welcome to Fishers Alley 5, a gorgeous getaway on Isle of Palms’ exclusive Wild Dunes Resort. Just a block and a half from the...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
Casa Flamingo Oceanfront Dreamhouse! 8 b...

Welcome to Casa Flamingo! Presented by Exclusive Properties on Isle of Palms. *Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. **Available all year! During the Summer months...

  • Isle of Palms
  • 8 Bedrooms
  • 6 Bathrooms
  • Sleeps 19
7 Beachwood East by AvantStay | Ocean Vi...

Step into the epitome of luxury and relaxation at 7 Beachwood East, a freshly constructed modern beach home located in a gated community just one lot back from the ocean. Ideal for family get-togethers or group getaways, this 7-bedroom masterpiece...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Waterway Views, Private Pool, Hot Tub, I...

Welcome to SEA'S THE DREAM! Just north of historic Charleston sits this striking 5 bedroom home with private pool and vistas of the spectacular Intracoastal Waterway on the Isle of Palms. It would surely be the ideal spot for your next vacation! ...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 12
1 Pelican- Easy Walk to Beach & Communit...

Fall Specials!Welcome to your ideal Isle of Palms hideaway! Located in a peaceful cul-de-sac within Wild Dunes Resort, 1 Pelican Bay is a elegantly appointed 5-bedroom beach home ideal for families and groups looking to relax, reconnect, and...

  • Isle of Palms
  • 5 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Casa Banana Oceanfront on Ocean Blvd, 6 ...

Welcome to Casa Banana! Presented by Exclusive Properties on Isle of Palms. *Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices include linens and cleaning!**Available...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 20
Ready to make Holiday Memories? IOP 7 bd...

Your luxury vacation awaits at this remarkable Isle of Palms beach estate. Composed of seven bedrooms, seven bathrooms, countless outdoor space, and a impressive backyard getaway with pool. With elegantly-designed interiors and unending amenities...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 16
311 Carolina by AvantStay | Rooftop Ocea...

311 Carolina Boulevard is really a rare find with ocean vistas, private pool, four cavernous decks, and impressive amenities to meet your every vacation wish. Step into your vacation dream that features five bedrooms, each with a king bed, four full...

  • Isle of Palms
  • 5 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
????Coastal Sunrise????Ocean Front on Oc...

**We are Saturday to Saturday in the Summer, but we have a 3 nighttime min in the off-season**--Description--Part of our Luxury Collection, 'Coastal Sunrise', 702 Ocean Blvd. is a six bedroom, six and a half bathroom, entirely remodeled (April 2022...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 14
Stunning Home! Pool, Theater Room, Steps...

Amazing luxury rental located on a peaceful street just a few steps to the beach boardwalk. Loaded with outdoor amenities including an broad backyard complete private pool, chaise loungers, and outdoor shower. Appreciate vistas of the ocean from the...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 11
Permanent Waves, Gorgeous home, Golf Cou...

8 Frank Sottile | Permanent WavesLocation: Isle of Palms, SCOverview:This striking home on the Isle of Palms was completely and luxuriously modernized in 2024. Located in a relaxing getaway by a pond with idyllic vistas of the Harbor Course, this...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Spacious Isle of Palms Beach Home with H...

Sandy CheeksLocation: 6 26th Ave Isle of Palms, SCOverview:Welcome to this completely refreshed 6-bedroom, 3-bathroom home on the elite Isle of Palms. Ideal for families or groups, this cavernous single-family home offers opulent amenities...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Seascapes 714 Ocean Blvd. Charming, Ocea...

**We are Saturday to Saturday in the Summer, but we have a 3 nighttime min in the off-season**--Description--'Seascapes' 714 Ocean Blvd, is a classic oceanfront home located in the esteemed Ocean Blvd. side of the island which places the beach just...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Modern Elegance Meets Island Charm & Pri...

The Rosemary House – Modern Elegance Meets Island CharmWelcome to The Rosemary House, a chic and sun-soaked getaway located just behind the gates of Wild Dunes Resort and mere steps from the pristine sands of Isle of Palms. This freshly...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
712 Ocean Blvd | New Build + Pool, Game ...

Sun, sand, and wellness collide at Stay Salty—a brand-new, oceanfront getaway on Isle of Palms where modern luxury meets intentional, healthy living. With six bedrooms (including 5 California King beds), six full bathrooms, and a powder room, this...

  • Isle of Palms
  • 6 Bedrooms
  • 7 Bathrooms
  • Sleeps 12
Beautifully Remodeled Modern, Yet Charmi...

Your Isle of Palms Heaven Awaits!✨Property Highlights- Private Pool & Putting Green- Ocean Vistas from Second Level- Modern Beachy Decor- Steps to Public Beach Access- $250 Beach Gear Credit with 3-14 nighttime stays!Please note that every...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12