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Isle of Palms, SC 4+ Bedroom Vacation Rentals

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180 rentals found
Sandcrab Court 18 by Wild Dunes, with Am...

Sandcrab Court 18 by Wild Dunes4 Bedroom Resort View Home4 Bedrooms | 2 Bathrooms | Sleeps 10DescriptionEscape to Sandcrab Court 18, a welcoming and roomy island getaway ideal for families and groups looking to experience the best of Isle of Palms...

  • Isle of Palms
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
AMAZING Golf and Ocean View Home! Privat...
5.0
(5)

Step inside 37 Ocean Point. A luxury five bedroom, five bathroom home in the Ocean Point neighborhood of the Wild Dunes community. Located at the very end of Wild Dunes, Ocean Point is highly sought-after due to its privacy, impressive and broad...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 10
Second row back from the beach, cornhole...

As of 10/30/2025 construction is now happening behind the home. One row back from the beach! This ocean view, 9 bedroom 6 and a half bath home is loaded with amenities for your family getaway. Charm and coastal style are found throughout this...

  • Isle of Palms
  • 9 Bedrooms
  • 6 Bathrooms
  • Sleeps 20
New Listing! Ask about discounts! 3900 P...

New to our luxury collection, 3900 Palm Blvd. is a gorgeous five bedroom oceanfront home. Welcome to your dream vacation home on the pristine shores of Isle of Palms, South Carolina. This grand five bedroom, four full bathrooms and two half baths...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
New Listing! Lagoon View, close to Beach...

Brand new to the rental program! Remodeled in 2024 with all rooms newly painted, refinished wood floors throughout, and a new kitchen. Incredible 5 Bedroom vacation home in the exclusive gated Ocean Point Community of Wild Dunes Resort. Access to...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Ideal Ocean Point Location- Close to Poo...

New Kitchen, PLUS Dining and Living Room Renovations! Close and convenient proximity to Ocean Point beach and pool. Please see aerial photos 35 and 36!Inquire about our long-term winter prices on stays of 30 days or more!Located in the private...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
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5.0
(12)

Island Time in 5Location: Isle of PalmsOverview:Welcome to I"sland Time in 5," a four bedroom, three and a half bath home, located in the Wild Dunes Resort on the handsome Isle of Palms. This beautiful home offers a private plunge pool, a sizable...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
Spacious Isle of Palms Beach Home with H...
5.0
(15)

Sandy CheeksLocation: 6 26th Ave Isle of Palms, SCOverview:Welcome to this completely refreshed 6-bedroom, 3-bathroom home on the elite Isle of Palms. Ideal for families or groups, this cavernous single-family home offers opulent amenities...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Golf Views, Private Pool, Screen Porch, ...
5.0
(2)

5 Bedroom, Private Pool, 12th Green on Harbor Course, Close to Isle of Palms Marina. $250 credit toward beach gear units with VayK Life (3-21 nights only). Ideal Family Getaway! Off season discounts and long-term units available until March 2025...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Seascapes~ 714 Ocean Blvd. Charming, Oce...

**We are Saturday to Saturday in the Summer, but we have a 3 nighttime min in the off-season**--Description--'Seascapes' 714 Ocean Blvd, is a classic oceanfront home located in the esteemed Ocean Blvd. side of the island which places the beach just...

  • Isle of Palms
  • 6 Bedrooms
  • 4 Bathrooms
  • Sleeps 14
Discounts!! Serenity- 2 50th~ One of a k...
5.0
(2)

Ask about our Summer 2025 discounts!! *During Summer months this home books Friday to Friday**Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote. --Description--New to our Luxury Collection...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Lux. IOP Beach 7 Bed Home, Christmas Wee...
5.0
(3)

Imagine watching the big game from your pool or hot tub... Your luxury vacation awaits at this remarkable Isle of Palms beach estate. Composed of seven bedrooms, seven bathrooms, countless outdoor space, and a impressive backyard getaway with pool...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 16
????DISCOUNTS! Rare 2nd Row, Luxury Home...
4.3
(6)

**124 Charleston Blvd is Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms**--Description--New to our luxury collection, 124 Charleston Blvd, 'Ocean's Genesis' is a rare gem. Be one of the first to experience this rare six...

  • Isle of Palms
  • 6 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Sawyer by AvantStay | Stunning Isle Of P...
4.6
(12)

Welcome to Sawyer, an AvantStay home! Located on the handsome beachy Isle of Palms just 30 mins. away from downtown Charleston, this home is a marvelous getaway for those looking for a calming spot a ideal distance from the action. Cook up some...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
????'Dolphin Manor' ~ OCEAN FRONT, PRIVA...

** During the summer and holidays we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **Description'Dolphin Manor' -512 Ocean Blvd, was completely refreshed Spring 2021 and is the ideal oceanfront home for your hideaway! With...

  • Isle of Palms
  • 6 Bedrooms
  • 6 Bathrooms
  • Sleeps 12
6 10th Avenue by AvantStay | Steps to th...
4.8
(6)

Sunshine we've got it! Now all we have to add is you to this much sought-after vacation hideaway! Conveniently located in Pavilion Place and just across from the beach, 6 10th Avenue is a shining 2,691 square foot home that has all the ingredients...

  • Isle of Palms
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 15
????Casa Margarita???? ~Oceanfront, 10BD...
4.8
(11)

Welcome to Casa Margarita!**904 Ocean Blvd. Presented by Exclusive Properties Vacation Rental Agency on Isle of Palms***Plug in your dates to see the full quote! Email us with any questions regarding the home or the quote or discounts. NOTE: Prices...

  • Isle of Palms
  • 10 Bedrooms
  • 11 Bathrooms
  • Sleeps 22
Pavilion a la Plage on Isle of Palms ~ P...

** During the summer we book Saturday to Saturday. Off-season we require a 3 nighttime minimum **--Description--As part of our Island Collection, 'Pavilion a la Plage' 4 10th Ave, is a seven bedroom, five and a half bathroom home located in the...

  • Isle of Palms
  • 7 Bedrooms
  • 5 Bathrooms
  • Sleeps 16